Hypotensive Effects of Beverages Containing Eucommia Leaf Glycosides on High Normotensive and Mild Hypertensive Subjects

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The hypotensive effects and safety aspect of beverages containing Eucommia leaf glycosides were examined in a randomized double-blind, placebo-controlled, parallel group study. The subjects were high normotensive and mild hypertensive adult male and female subjects. Test or placebo meals were given one time per a day for 12 weeks.<br>The results revealed that the systolic blood pressure (SBP) was significantly reduced after 4 weeks of intake in the test-meal group. The diastolic blood pressure (DBP) was also significantly reduced after 6 weeks of intake. In contrast, no changes in blood pressure were observed during the trial in the placebo group. Between the two groups, there was a significant difference in SBP at 8, 10, and 12 weeks and in DBP at 10 and 12 weeks. No significant abnormal changes were observed in the results of blood examination, urinalysis, and physical examination. Additionally, clinically relevant adverse effects such as digestive tract symptoms, dry cough, or allergic phenomena were not observed in association with test-meal intake. Thus, these results demonstrated the benefits and safety of beverages containing Eucommia leaf glycosides in high normotensive and mild hypertensive subjects.

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詳細情報 詳細情報について

  • CRID
    1390282680265290240
  • NII論文ID
    130004951497
  • DOI
    10.3387/iseu.1.47
  • ISSN
    18823319
    18815111
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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