Single L-Tyrosine administrariotn Alters Brain Monoamine Levels in Roborovskii Hamsters

DOI Web Site
  • KABUKI Yusuke
    Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University
  • YAMANE Haruka
    Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University
  • SHIGEMI Kazutaka
    Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University
  • HAMASU Kousuke
    Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University
  • FURUSE Mitsuhiro
    Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University

Bibliographic Information

Other Title
  • L-チロシンの単回投与はロボロフスキーハムスターの脳内モノアミン含量を変化させる
  • Single L-tyrosine administration alters brain monoamine levels in Roborovskii hamsters

Search this article

Abstract

The Roborovskii hamster （P. roborovskii） has high locomotor activity （hyperactivity）and low dopamine levels in the brain compared with the congeneric Djungarian hamster （P. sungorus）. In the present study, we investigated the effects of acute administration of L-tyrosine, the primary precursor of dopamine, on the locomotor activity of and brain monoamine levels in Roborovskii hamsters to clarify the efficacy of L tyrosine in ameliorating signs of hyperactivity such as those observed in hyperactive dogs. Acute administration of L-tyrosine had no effect on locomotor activity in the open field, but increases in dopamine and norepinephrine turnover rates and decrease in serotonin turnover rate in the brain were observed. These findings suggest that acute feeding of L-tyrosine may be effective in modifying brain monoamine metabolism,but not ameliorating signs of hyperactivity in the Roborovskii hamster.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top