Development of a cell microarray chip system for early and accurate malaria diagnosis

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Other Title
  • 細胞チップを用いた迅速高感度マラリア感染症診断法の開発
  • 細胞チップを用いた迅速高感度マラリア感染症診断法の開発 : 200万分の1の感染を見出しマラリアに立ち向かう
  • サイボウ チップ オ モチイタ ジンソク コウカンド マラリア カンセンショウ シンダンホウ ノ カイハツ : 200マンブン ノ 1 ノ カンセン オ ミダシ マラリア ニ タチムカウ
  • — 200万分の1の感染を見出しマラリアに立ち向かう —
  • — Finding one parasite in 2 million erythrocytes for elimination of malaria —

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Description

Early and accurate diagnosis of malaria is needed to prevent the spread of this parasite. To this end, we developed a novel microarray chip system for the detection of malaria, and evaluated it in Africa. A chip with approximately 20,000 microchambers was developed to detect malaria parasites (hereafter called a cell chip). Leukocytes were removed by filtration columns from whole blood cells. An erythrocyte suspension containing fluorescent nuclear staining dye was dispersed onto the cell chip surface and washed, creating an erythrocyte monolayer in each microchamber that contains more than 2 million erythrocytes. Malaria parasite-infected erythrocytes are then detected using a fluorescence detector. Accurate and rapid detection of the parasites with high sensitivity was achieved by the developed system.

Journal

  • Synthesiology

    Synthesiology 10 (1), 33-40, 2017

    National Institute of Advanced Industrial Science and Technology

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