Effects of Use Notification Policy for Various Classes of Antimicrobial Agents on Consumption of Antimicrobial Agents and Antimicrobial Resistance
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- TANAKA Dai
- Department of Pharmacy, Toshiba Hospital
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- FUKASAWA Suzuko
- Department of Clinical Laboratory, Toshiba Hospital
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- KIKO Yasuhiro
- Department of Pharmacy, Fujisawa City Hospital
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- KINOSHITA Kaori
- Department of Nursing, Toshiba Hospital
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- SAKAGUCHI Mikiyo
- Department of Nursing, Toshiba Hospital
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- FUJIE Toshihide
- Department of Internal Medicine, Toshiba Hospital
Bibliographic Information
- Other Title
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- 抗菌薬の幅広い使用届出制が処方動向及び薬剤感受性に及ぼす効果
- コウキンヤク ノ ハバヒロイ シヨウ トドケデセイ ガ ショホウ ドウコウ オヨビ ヤクザイ カンジュセイ ニ オヨボス コウカ
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Abstract
Inappropriate use of antimicrobial agents causes unnecessary patient exposure to medication and emergence of antibiotic resistance. Our institution started to use a notification policy for various classes of antimicrobial agents (carbapenems, fourth-generation cephalosporins and quinolones, ceftazidimes, and antimethicillin-resistant Staphylococcus aureus (MRSA) agents) from November 2005. In this study, consumption of the antimicrobial agents for every half year and the trends of antimicrobial resistance were verified before and after the introduction of the notification policy, and the system was evaluated. Total antimicrobial usage density (AUD) of broad-spectrum antimicrobial agents (i.e. carbapenems, fourth-generation cephalosporins and quinolones) was decreased from 34.1 to 16.0 (p<0.01). The incidence of Pseudomonas aeruginosa isolates resistant to imipenem/cilastatin (IPM/CS) and levofloxacin (LVFX) showed decreasing trends. The detection rate of MRSA was significantly decreased (p<0.05). Multidrug-resistant Pseudomonas aeruginosa (MDRP) and extended-spectrum beta-lactamase (ESBLs) producing enterobacteria were not detected. In contrast, the AUD of anti-MRSA agents was not changed. Education about the effectiveness and appropriate use of anti-MRSA agents was given before the introduction of the notification policy. Therefore, the notification policy for agents to prevent the emergence of resistance may be ineffective. The present study indicates that our notification policy for various classes of antibiotics is effective for reducing excessive broad-spectrum antibiotic use, and control over nosocomial infections in the settings of antimicrobial agents was not used appropriately.<br>
Journal
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- Japanese Journal of Infection Prevention and Control
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Japanese Journal of Infection Prevention and Control 23 (5), 361-365, 2008
Japanese Society for Infection Prevention and Control
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Details 詳細情報について
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- CRID
- 1390282680273287296
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- NII Article ID
- 10024359257
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- NII Book ID
- AA12313188
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- ISSN
- 18832407
- 1882532X
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- NDL BIB ID
- 9731413
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed
