Principal Component Analysis of Factors Affecting Methicillin-Resistant Staphylococcus aureus Isolation Rates

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  • HAMADA Yukihiro
    Department of Infection Control and Prevention, Aichi Medical University Department of Pharmacy, Aichi Medical University Center for Anti-infective Research and Development, Hartford Hospital
  • YAMAGISHI Yuka
    Department of Infection Control and Prevention, Aichi Medical University Department of Clinical Infectious Diseases, Aichi Medical University
  • KATO Yukiko
    Department of Infection Control and Prevention, Aichi Medical University
  • SUEMATSU Hiroyuki
    Department of Infection Control and Prevention, Aichi Medical University
  • OKAMAE Tomoko
    Department of Infection Control and Prevention, Aichi Medical University
  • KURUMIYA Ai
    Department of Infection Control and Prevention, Aichi Medical University
  • HIRAI Jun
    Department of Infection Control and Prevention, Aichi Medical University Department of Clinical Infectious Diseases, Aichi Medical University
  • KAWASUMI Noriyo
    Department of Infection Control and Prevention, Aichi Medical University Department of Pharmacy, Aichi Medical University
  • MATSUURA Katsuhiko
    Department of Pharmacy, Aichi Medical University
  • MIKAMO Hiroshige
    Department of Infection Control and Prevention, Aichi Medical University Department of Clinical Infectious Diseases, Aichi Medical University

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Other Title
  • 主成分分析を用いたMRSA検出率の要因探索
  • シュセイブン ブンセキ オ モチイタ MRSA ケンシュツリツ ノ ヨウイン タンサク

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Abstract

  Methicillin-resistant Staphylococcus aureus (MRSA) is an important pathogenic bacterium causing nosocomial infections. Using data from patients hospitalized between April 2012 and June 2013 in our hospital, we examined how the use of antibiotics and hand disinfectants affected the MRSA isolation rates. The antimicrobial use density (AUD), use of disinfectants, and MRSA isolation rates from all samples and blood culture samples were correlated for disinfectants (r=−0.34). Higher AUD of carbapenem (r=0.61), first-generation cephalosporin (r=0.59), and quinolone (r=0.48) were also correlated with increased MRSA isolation rates. Multidimensional analysis was performed to evaluate contribution to MRSA isolation rates. In the first analysis, the disinfectant had a contribution ratio of 20.7%. In the second analysis, the AUD of carbapenem had a contribution ratio of 12.7%. The cumulative contribution ratio of disinfectant plus AUD of carbapenem was 86.7%. This new analytic method allowed visualization and has contributed to reducing MRSA isolation rates.<br>

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