Effect of Broad Spectrum Antimicrobial Agents Use Monitoring Policy on Drug Resistance in Pseudomonas aeruginosa
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- SOEDA Hiroshi
- Department of Pharmacy, Tokyo Medical University Hospital Department of Infection Control and Prevention, Tokyo Medical University Hospital
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- KANEKO Akiko
- Department of Pharmacy, Tokyo Medical University Hospital Department of Infection Control and Prevention, Tokyo Medical University Hospital
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- INUBUSE Atsuo
- Department of Pharmacy, Tokyo Medical University Hospital
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- AKASHI Takao
- Department of Pharmacy, Tokyo Medical University Hospital
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- CHIBA Katsumi
- Department of Clinical Laboratory, Tokyo Medical University Hospital Department of Infection Control and Prevention, Tokyo Medical University Hospital
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- SATOH Kumi
- Department of Infection Control and Prevention, Tokyo Medical University Hospital
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- KUSAMA Yumiko
- Department of Infection Control and Prevention, Tokyo Medical University Hospital
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- NAKAMURA Itaru
- Department of Infection Control and Prevention, Tokyo Medical University Hospital
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- MATSUNAGA Naohisa
- Department of Infection Control and Prevention, Tokyo Medical University Hospital
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- KOSHIHARA Kimihito
- Department of Infection Control and Prevention, Tokyo Medical University Hospital
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- MATSUMOTO Tetsuya
- Department of Infection Control and Prevention, Tokyo Medical University Hospital
Bibliographic Information
- Other Title
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- 広域抗菌薬使用への使用調査制による介入が緑膿菌の抗菌薬感受性に及ぼす効果
- コウイキ コウキンヤク シヨウ エ ノ シヨウ チョウサセイ ニ ヨル カイニュウ ガ リョクノウキン ノ コウキンヤク カンジュセイ ニ オヨボス コウカ
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Abstract
Overuse of antimicrobial agents may lead to increased drug resistance in various strains of bacteria. Our institution started a use monitoring policy for broad spectrum antimicrobial agents. In this study, Antimicrobial use density (AUD) of carbapenem (CBPM) and fluoroquinolone (FQ) antimicrobial agents for every half year between April 1, 2007 and March 31, 2009 and the trends of resistance to IPM/CS and CPFX of Pseudomonas aeruginosa were analyzed to evaluate the use monitoring policy. The resistance rates to IPM/CS and CPFX were decreased from 29% and 20% to 21% and 15%, respectively. Mean administration days and long-term administration rates of CBPM were decreased from 7 days and 32% to 6 days and 24%, respectively, and the AUD of CBPM showed slightly decreasing trends. In contrast, the AUD of FQ showed little change. The present study indicates that the use monitoring policy was effective for reducing carbapenem antimicrobial agent use, and reduces the antimicrobial resistance of P. aeruginosa.<br>
Journal
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- Japanese Journal of Infection Prevention and Control
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Japanese Journal of Infection Prevention and Control 25 (3), 158-162, 2010
Japanese Society for Infection Prevention and Control
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Keywords
Details 詳細情報について
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- CRID
- 1390282680275143936
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- NII Article ID
- 10027820737
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- NII Book ID
- AA12313188
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- ISSN
- 18832407
- 1882532X
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- NDL BIB ID
- 10722066
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed