Cyclization, Ring‐Expansion, and Several Cascade Reactions Utilizing Allenylic Molecular Structure Characteristics
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- Nagao Yoshimitsu
- Faculty of Pharmaceutical Sciences, The University of Tokushima
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- Sano Shigeki
- Faculty of Pharmaceutical Sciences, The University of Tokushima
書誌事項
- タイトル別名
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- Cyclization, Ring-Expansion, and Several Cascade Reactions Utilizing Allenylic Molecular Structure Characteristics
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説明
Various kinds of new reactions based on allenylic molecular structure characteristics have been described. Specifically, mild alkaline hydrolysis of diethyl α-acetylamino (or methoxy) -α-alkynylmalonates generates conjugated allenyl esters which promote 5-endo-mode heterocyclic cyclization giving trisubsutituted oxazoles, SH-enzyme inhibition, new chiral pyrrolinones (cathepsin B inhibitors) formation, and Myers-type biradical aromatization in a cascade reaction manner. Systematic ortho vicinal-endo-mode-, geminal spiro-endo-mode-, and meta ansa-endo-mode-cyclization reactions have been accomplished by using numerous conjugated allenyl ketones and Lewis acids. Base-mediated and palladium (0) -catalyzed cascade heterocyclic and carbocyclic ring-expansion reactions have been achieved by using hydroxy-substituted allenyl cyclic compounds.
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 61 (11), 1088-1098, 2003
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390282680287473024
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- NII論文ID
- 10011908536
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- NII書誌ID
- AN0024521X
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- COI
- 1:CAS:528:DC%2BD3sXptVajur4%3D
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- ISSN
- 18836526
- 15222667
- 00379980
- 09317597
- http://id.crossref.org/issn/00379980
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- NDL書誌ID
- 6760255
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- 本文言語コード
- en
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- データソース種別
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- NDLサーチ
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