The Insertion of Carbon Monoxide by Use of Pd<SUP>II</SUP> and PPh<SUB>3</SUB>

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  • BAN Yoshio
    Faculty of Pharmaceutical Sciences, Hokkaido University
  • MORI Miwako
    Faculty of Pharmaceutical Sciences, Hokkaido University

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  • Ｐｄ?QＩＩ?R‐ＰＰｈ?S３?Tを用いるＣＯそう入反応
  • Pd2 PPh3 オ モチイル CO ソウニュウ ハンノウ

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Abstract

It has been so far reported that the reaction of carbon monoxide with aryl or vinyl halides in the presence of alcohol or amine smoothly proceeded under atmospheric pressure by use of a catalytic amount of PbII and PPh3 to give esters or amines in good yields. This reaction was extended by us to the synthesis of heterocyclic compounds. The aryl halide having the internal amino, hydroxy and amido groups gave the benzolactams, benzolactones and imido derivatives. A variety of heterocyclic compounds including sendaverine (alkaloid) and anthramycine derivatives (antibiotics) were synthesized by this intramolecular cyclization.

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