書誌事項
- タイトル別名
-
- Studies on the Use of Trityl Group in Peptide Synthesis
- トリチルキ オ ホゴキ ト スル ペプチド ゴウセイ ニ カンスル ケンキュウ
この論文をさがす
説明
An industrial method for the synthesis of peptides using a trityl group as the protecting group has been investigated.<BR>The derivatives of the amino acids, containing a liophilic group in their side chain, such as γ-methyl, ethyl and benzyl glutamate, β-methyl, ethyl and benzyl aspartate and S-trityl cystein, were N-tritylated directly in good yields with 2-equiv. of trityl chloride in aprotic solvents in the presence of triethyl amine. In these reactions, it was found that the α-carboxyl group of amino acids derivatives was simultaneously tritylated during the N-tritylating process.<BR>Using these trityl derivatives, glutathione (GSH), α-aminobenzyl penicilline (ABP) and aspartyl phenylalanine methyl ester (APAM) were prepared in good yields.
収録刊行物
-
- 有機合成化学協会誌
-
有機合成化学協会誌 29 (6), 599-604, 1971
公益社団法人 有機合成化学協会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282680287913472
-
- NII論文ID
- 130000926686
-
- NII書誌ID
- AN0024521X
-
- ISSN
- 18836526
- 00379980
-
- NDL書誌ID
- 8467017
-
- データソース種別
-
- JaLC
- NDLサーチ
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可