Total Synthesis of Naturally Occurring Quinones
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- NARUTA Yoshinori
- Department of Chemistry, Faculty of Science, Kyoto University
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- MARUYAMA Kazuhiro
- Department of Chemistry, Faculty of Science, Kyoto University
Bibliographic Information
- Other Title
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- 天然産キノンの合成研究
- テンネンサン キノン ノ ゴウセイ ケンキュウ
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Abstract
New syntheses of naturally occurring quinones with high physiological activities are described in this review. Synthetic strategies of these quinones are based on the regio- (and/or stereo-) selective introduction of allylic or 2, 4-pentadienyl side chains directly to quinones with the corresponding organosilanes and -stannanes. This review contains the following topics; (i) allylorganostannanes as efficient allylating reagents to quinones, and regio- and stereoselective synthesis of polyprenylquinones, i. e. coenzyme Qn, vitamin K, (ii) methyl 2-triorganosily1-3-butenoate as a new synthon of 3-methylcarbonylallyl anion and its application to the synthesis of pyranonaphthoquinone antibiotics, i. e. (±) -nanaomycin A, (±) -deoxyfrenolicin, (iii) biomimetic AB ring synthesis of an aglycone of an anthracycline antibiotic, aklavinone, by means of intramolecular electron relay system, (iv) synthesis of 11-deoxydaunomycinone precursor by means of intramolecular Diels-Alder reaction, (v) novel synthesis of pyrrolo [1, 2-a] -indol-5, 8-quinone by means of intramolecular cyclization and application to the synthesis of mitosenes.
Journal
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- Journal of Synthetic Organic Chemistry, Japan
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Journal of Synthetic Organic Chemistry, Japan 42 (5), 415-428, 1984
The Society of Synthetic Organic Chemistry, Japan
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Details 詳細情報について
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- CRID
- 1390282680287942400
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- NII Article ID
- 130000930731
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- NII Book ID
- AN0024521X
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- ISSN
- 18836526
- 00379980
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- NDL BIB ID
- 2984661
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed