書誌事項
- タイトル別名
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- Preparation of pH Responsive Nanogels Based on the Precise Synthesis of Heterotelechelic Poly(ethylene glycol)s for Pinpoint Cancer Diagnosis and Therapy
- ヘテロニ カンノウセイ ポリエチレン グリコール ノ セイミツ ゴウセイ ニ モトズイタ pH オウトウセイ ナノゲル リュウシ ノ チョウセイ ト ガン ノ ピンポイント シンダン チリョウ エノ オウヨウ
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We described here novel approach to the precise synthesis of the heterotelechelic PEG deriva-tives to prepare pH-responsive PEGylated nanogels for pinpoint cancer diagnosis and therapy. In particular, use of potassium 3, 3-diethoxy-1-propanolate as an initiator for the polymerization of ethylene oxide gave various heterotelechelic PEGs with well-defined structure, high yield, and high purity. The pH-responsive PEGylated nanogels composed of cross-linked poly[2-(N, N-diethylamino) ethyl methacrylate] (polyamine) core and PEG tethered chains bearing a functional group(acetal group or carboxylic acid group) as a platform moiety for the installation of ligand molecules were synthesized by emulsion polymerization of vinyl benzyl group-ended heterotelechelic PEG, amine monomer, and cross-linker. In addition, PEGylated nanogels show unique properties and functions in synchronizing with the reversible volume phase transition of the polyamine gel core in response to pH. We list some of the biomedical applications of the nanogels, including tumor-specific 19F MRI probes and tumor-specific drug delivery carriers.
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 66 (5), 428-435, 2008
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390282680288574976
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- NII論文ID
- 10021174866
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- NII書誌ID
- AN0024521X
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- ISSN
- 18836526
- 00379980
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- NDL書誌ID
- 9503834
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 使用不可