Catalytic Enantioselective Reactions by the Chiral Cobalt Complexes as Lewis Acid Catalysts

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  • Kezuka Satoko
    青山学院大学理工学部化学・生命科学科
  • Mita Tsuyoshi
    東京大学大学院薬学系研究科
  • Iwakura Izumi
    慶應義塾大学大学院理工学研究科基礎理工学専攻
  • Ikeno Taketo
    Department of Chemistry, Faculty of Science and Technology, Keio University
  • Yamada Tohru
    Department of Chemistry, Faculty of Science and Technology, Keio University

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  • 光学活性コバルト錯体をルイス酸として用いる触媒的不斉合成反応
  • コウガク カッセイ コバルト サクタイ オ ルイスサン ト シテ モチイル ショクバイテキ フセイ ゴウセイ ハンノウ

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Abstract

This article is focused on the chiral Lewis acid catalyses by the optically active ketoiminatocobalt complexes. Screening of the central metal of the ketoiminato complex catalysts for the enantioselective hetero Diels-Alder reaction revealed that cobalt was the most effective for affording the corresponding pyranone derivatives. The corresponding cationic cobalt (III) complexes were developed as an efficient Lewis acid catalyst and subjected to the hetero Diels-Alder reaction and the carbonyl-ene reaction. It was found that their counter anions significantly influenced the reactivity and the enantioselectivity in the carbonyl-ene reaction. The cationic cobalt (III) complexes could be employed as the efficient catalysts for the enantioselective 1, 3-dipolar cycloaddition reaction. Because of the competitive coordination of the nitrone, the 1, 3-dipolar cycloaddition with the monodentate α, β-unsaturated aldehyde has been limited to several catalyses, although these cationic cobalt (III) complexes effectively catalyzed the reaction to afford the isoxazoline derivative with high-to-excellent stereoselectivities. These types of cobalt complex catalystscould be applied to the enantioselective Henry reaction even in the Presence of amine baces and the enantioselective chemical fixation of carbon dioxide to obtain the optically active cyclic carbonate.

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