Syntheses of 3, 6-Disubstituted-2-amino-4-phenylquinolines from 2-Aminobenzophenones

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  • KWON Sundo
    Department of Applied Chemistry, Faculty of Engineering, University of Osaka Prefecture
  • TANAKA Shinobu
    Department of Applied Chemistry, Faculty of Engineering, University of Osaka Prefecture
  • ISAGAWA Kakuzo
    Department of Applied Chemistry, Faculty of Engineering, University of Osaka Prefecture

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Other Title
  • 2-アミノベンゾフェノン類から3, 6-二置換-2-アミノ-4-フェニルキノリン類の合成
  • 2-アミノベンゾフェノンルイ カラ 3 , 6-ニ チカン-2-アミノ-4-フェニルキノリンルイ ノ ゴウセイ
  • <I>o</I>-アミノベンゾフェノン誘導体 (第12報)

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Description

3, 6-Disubstituted-2-amino-4-phenylquinolines (1) were obtained in 3295% yields by the reaction of 5-substituted-2-aminobenzophenones (substituents of 5-position are H, Cl or CH3) with α-substituted acetonitriles (substituents are H, CH3 or C6H5) in the presence of NaH as a basic catalyst in pyridine. 3-Cyano derivatives in (1) were given in 9598% yields by the reaction of 5-substituted-2-aminobenzophenones with malononitriles in the presence of C2H5ONa in ethanol.

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