Recent Advances in Chemical Synthesis of Oligonucleotides by the Use of 5- Chloro - 8- quinolyl Group

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  • TAKAKU Hiroshi
    Department of Industrial Chemistry, Chiba Institute of Technology

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  • ５‐クロロ‐８‐キノリル基を用いたオリゴヌクレオチドの化学合成における最近の展開
  • 5 クロロー8 キノリルキ オ モチイタ オリゴ ヌクレオチド ノ カガク ゴ

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Description

The synthesis of oligonucleotides by the use of 5-chloro-8-quinolyl group has been described. This group can be successfully used as a phosphate protecting group of internucleotidic bonds in the synthesis of oligonucleotides by the phosphotriester approach. A new condensing and phosphorylating reagents are also described in detail.

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