ジアステレオマー塩法による光学分割の効率化を目指して

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タイトル別名
  • Toward Efficient Optical Resolution by Diastereomeric Salt Formation
  • ジアステレオマーエンホウ ニ ヨル コウガク ブンカツ ノ コウリツカ オ メザシテ

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説明

In order to overcome trial-and-error situation in the enantioseparation by the diastereomeric salt formation, we carried out systematic studies on the enantioseparation of racemic 1-arylethylamines with/without a substituent on the aryl group by using enantiopure arylglycolic acids. The studies revealed that there are three factors for the growth and stabilization of less-soluble diastereomeric salt crystals; 1)infinite hydrogen bonding interaction to form a 21-column, which enables a crystal to grow in one dimension, 2)effective van der Waals interaction between the columns to make the crystal growable in a three-dimensional manner, and 3)sufficient CH-π interaction in/between the columns, which also play an important role for three-dimensional crystal growth. On the basis of the observations, we propose molecular length rule and aromatic ring rule, which realize efficient van der Waals interaction and CH-π interaction, respectively.<br>Keeping in mind of these requirements for the molecular structure of a resolving agent, we industrialized an elegant process for the enantioseparation of racemic 1-phenylethylamine into the (R)-form, which is one of the most valuable chiral auxiliaries in the synthesis of drugs/drug intermediates in industrial scales, with (R)-mandelic acid upon optimizing conditions such as solvent, molar ratio, concentration, temperature, and additive, as well as the recycling process of (R)-mandelic acid and the racemizing process of (S)-1-phenylethylamine remained.

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