不斉合成バイオ触媒―Ｃｈｉｒａｌｓｃｒｅｅｎ―

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  • 林 素子
    ダイセル化学工業株式会社CPIカンパニーライフサイエンス開発センター

書誌事項

タイトル別名
  • Biocatalyst for Asymmetric Synthesis-Chiralscreen-
  • フセイ ゴウセイ バイオ ショクバイ Chiralscreen

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抄録

Chiralscreen® is biocatalyst, i.e. enzyme for asymmetric synthesis. Chiralscreen® OH for chiral alcohols and Chiralscreen® NH for chiral amino acids and amines are available. It catalyzes the desired reaction in high regio/stereo selectivity under mild conditions without dangerous reagents. For example, chemical reduction requires hydride reagent or hydrogen, however, pseudo-hydride donor of reduction with Chiralscreen® is formate or glucose. The solvent is water, and the reactions proceeds under ambient pressure and room temperature. Therefore, special facilities and safety counterplans are not needed for the reactions. The solubility of substrate in the water is not essential for the reaction. We have an example that slightly soluble ketone (solubility in water is 0.05%) is reduced quantitatively in perfect selectivity. Chiralscreen® is produced using recombinant cell, however, endotoxin, DNA, and/or proteins derived from microbe are not detected in the product.

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