書誌事項
- タイトル別名
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- Carbon-Carbon and Carbon-Hydrogen Bond Transformations Mediated by Highly Reactive Radicals and Their Application to the Synthesis of Bioactive Compounds
- コウハンノウセイ ラジカルシュ ガ ユウキスル タンソ タンソ オヨビ タンソ スイソ ケツゴウ ヘンカン ト セイブツ カッセイ ブッシツ ゴウセイ エノ カツヨウ
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Reactive free radicals have wide applications in organic synthesis due to their remarkable chemical properties that allow useful molecular transformations. The present review covers the author's recent studies on the utilization of radical species in chemical synthesis of organic molecules : The first topic deals with two types of alkoxyl radicals (primary or tertiary) that selectively undergo dehydrogenation or β-scission to give rise to the key structural elements of (-) -CP-263, 114, a ras-farnesyl transferase inhibitor. The second part of this review describes the development of new carbon-carbon bond forming reactions that proceed via the direct and selective abstraction of the hydrogen from the sp3C-H bond adjacent to oxygen or nitrogen. In this radical C-H bond transformation, triethylborane serves not only as a source of hydrogen abstractor but as an alkoxyl radical scavenger that enables the irreversible addition of carbon radicals to carbon-oxygen double bonds.
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 65 (7), 665-676, 2007
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390282680289329792
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- NII論文ID
- 10019519656
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- NII書誌ID
- AN0024521X
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- ISSN
- 18836526
- 00379980
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- NDL書誌ID
- 8887311
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可