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- 秋田 弘幸
- 東邦大学薬学部
書誌事項
- タイトル別名
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- Natural Products Syntheses Based on the Biotransformation Using Hydrolases
- カスイ ブンカイ コウソ ニ ヨル ブッシツ ヘンカン オ キバン ト シタ テンネンブツ ゴウセイ
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This review summarizes the chemoenzymatic syntheses of biologically active natural products based on a combination of chemical diastereoselectivity and enzymatic enantioselectivity using lipase. Both primary alcohols possessing a chiral center at β-position of hydroxyl group and secondary alcohols were subjected to the lipase-assisted acylation in the presence of acyl donor to afford the optically active esters and the optically active alcohols corresponding to the starting material. These optically active compounds were converted to the biologically active natural products such as bisabolane type sesquiterpenes, oudemansins, nikkomycins B and Z, chuangxinmycin, cystothiazoles and melithiazols possessing antifungal and cytotoxicic activities, inhibition of NADH oxidation, etc.
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 65 (8), 783-794, 2007
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390282680289339136
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- NII論文ID
- 10019753565
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- NII書誌ID
- AN0024521X
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- ISSN
- 18836526
- 00379980
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- NDL書誌ID
- 8918032
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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