書誌事項
- タイトル別名
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- Study on the Method for Oligosaccharide Synthesis Covering the Structural Diversity of Sialic Acid-Aiming at the Understanding of the Polymorphous Functions at the Molecular Level-
- シアルサン ブンシ タヨウセイ オ モウラ スル トウサ ゴウセイホウ ノ カイタク シアロ トウサ タキノウセイ ノ ブンシ リカイ オ メザシテ
- Aiming at the Understanding of the Polvmorhhous Functions at the Molecular Level
- シアロ糖鎖多機能性の分子理解を目指して
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抄録
For the purpose of the scrutiny of multi-functions of oligosaccharides at the molecular level, the practical method for the chemical construction is essential. In 1989, we have established the practical method for α-selective sialylation that utilizes nitrile solvent effect to fashion thermodynamically-disfavored equatorial glycoside. Due to the powerful method, we have succeeded in many first syntheses of sialyl oligosaccharide complexes such as sialyl Lewis X, GQ 1 b.<BR>Recently, we have developed highly reactive N-Troc-protected sialyl donor and 1, 5-lactamized sialyl acceptor. N-Troc sialyl donor enabled us to perform high-yielding sialylation, and obtained sialoside could be pivotally derived into various homologues containing Neu 5 Gc, NeuNH2 and 8-O-sulfo-Neu 5 Ac. Further, the synergic coupling with 1, 5-lactamized acceptor produced α(2-4) -and α(2-8) -linked disialic acid sequences in high yields, thereby resulting in the first synthesis of glycan portions of gangliosides HLG-2 and Hp-s 6.
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 64 (5), 481-491, 2006
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390282680289463424
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- NII論文ID
- 10017486696
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- NII書誌ID
- AN0024521X
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- COI
- 1:CAS:528:DC%2BD28XlsVKqsbc%3D
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- ISSN
- 18836526
- 00379980
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- NDL書誌ID
- 7959959
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可