Design and Characterization of Partially Fluorinated Lipid Liquid-Crystal Membranes as Biomaterials

DOI Web Site 5 Citations 70 References
  • Takagi Toshiyuki
    Organ Development Research Laboratory, National Institute of Advanced Industrial Science and Technology (AIST)
  • Takai Katsuki
  • Baba Teruhiko
    Organ Development Research Laboratory, National Institute of Advanced Industrial Science and Technology (AIST)
  • Kanamori Toshiyuki
    Organ Development Research Laboratory, National Institute of Advanced Industrial Science and Technology (AIST)

Bibliographic Information

Other Title
  • バイオ材料としての部分含フッ素脂質液晶膜の設計と特性化
  • バイオ ザイリョウ ト シテ ノ ブブン ガン フッソ シシツ エキショウ マク ノ セッケイ ト トクセイカ

Search this article

Abstract

This article reviews our approaches for designing fluorinated lipid liquid–crystal membranes suitable for biomaterials such as membrane protein reconstitution matrices. We proposed several partially fluorinated fatty acids as well as phospholipids bearing long (C18) hydrophobic chains comparable to biomembrane lipids. The fatty acids and/or phospholipids containing perfluoroalkyl group was easily synthesized in good yields. Judging from the collapse (equilibrium spreading) pressures of the proposed fatty aids and/or phospholipids at the air–water interface, the partial fluorination of hydrophobic chains was enough to improve their monolayer stability. The fluorinated phospholipid with C–C triple bonds formed flexible structures such as stable vesicles in water at a room temperature. The partially fluorinated phospholipids are applicable to protein reconstitution matrices, e.g., reconstitution of photosynthetic membrane proteins.

Journal

Citations (5)*help

See more

References(70)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top