動脈硬化症の成り立ちに関する実験病理学的研究

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タイトル別名
  • EXPERIMENTAL STUDIES ON THE MORPHOGENESIS OF ARTERIOSCLEROSIS
  • ドウミャク コウカショウ ノ ナリタチ ニ カンスル ジッケン ビョウリガクテキ ケンキュウ

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To elucidate the morphogenesis of cellulofibrous intimal thickening of the arteries which is regarded as a primary form of arteriosclerosis, the left common carotid arteries of rabbits and guinea-pigs were invested with various materials and by methods.<BR>In the invested segments of the arteries, it would be expected that the medial muscle cells are degenerated by cut of the vasa vasorum and the local hemodynamics are changed by means of constriction and or fixation.<BR>1) On both edges of the invested segment marked intimal thickenings were always revealed, on the contrary in the central part of the segment in which medial muscle cells predominantly disappeared the thickening seldom occured. Whenever the arteries were invested by tube having a small window in the midportion, on the surrounding area of the window the intimas also thickened.<BR>In these portions medial muscle cells would be relatively injured by oxygen deficiency and hemodynamic stress would be most effectively acted on the vessel wall.<BR>2) When the arteries were loosely tubed, medial changes were moderate and diffuse slight intimal thickening was observed over all invested segment.<BR>3) By means of bending and constriction of the arterial wall the intima proliferated in certain portions.<BR>4) Increase of permeability at thickened intimas were proved by the intravenous injection of trypan blue, carbon particles and fluorescent fibrinogen which had been injected.<BR>5) It was clarified that the muscle cells in the intima were drived from the medial muscle cells and endothelial cells.<BR>6) Both some degree of the malnutrition of the arterial wall and mechanical in juries of the arterial wall by hemodynamics were emphasized as causative factors on the morphogenesis of the arteriosclerosis. These two factors induced increase of vascular permeability and stagnation of tissue fluid in the arterial wall. Consequently cells consisting of the arterial wall reacted on plasma protein which is insudated and stagnated in the wall, and then proliferated. Also, regenerative proliferation of the cells occured.<BR>The proliferation of the cells followed cellulofibrous intimal thickening of the artery, namely arteiosclerosis.

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