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- 平井 裕一郎
- 群馬大学医学部第一外科学教室
書誌事項
- タイトル別名
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- EFFECTS OF CENTRAL NEUROTROPIC DRUGS ON CINCHOPHEN-INDUCED GASTRIC LESIONS IN RATS
- Cinchophen ニ ヨル ラット ノ イ ビョウヘン ニ オヨボス コウ チュウスウ シンケイヤク ノ エイキョウ
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説明
Sodium cinchophen was administered intraperitoneally in doses ranging from 20 to 50mg/ 100g body weight to adult male Holtmman rats. There occurred motor ataxia, somnolence, irritability, spasm, hyperglycemia, eosinopenia, hypothermia and acute hemorrhagic erosions in the glandular stomach. The dose of 40mg/100g body weight was found to be most useful for experimental study of gastric lesions.<BR>Luminal, Dazepam, Chlordiazepoxide, Morphine, Hydroxyzine and Cyiproheptadine proved effective preventing the production of gastric lesions. Therefore, it is suggested that the middle typothalamic area plays a vital role in producing the cinchophen gastric lesions in the rat. The effects of these cetral neurotropic drugs on the gastric lesions did not necessarily correlated with those of the symptoms following cinchophen admiuistraton.
収録刊行物
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- 北関東医学
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北関東医学 20 (2), 76-84, 1970
北関東医学会
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詳細情報 詳細情報について
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- CRID
- 1390282680305954944
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- NII論文ID
- 130003452612
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- NII書誌ID
- AN10585677
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- ISSN
- 13432826
- 18836135
- 00231908
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- NDL書誌ID
- 8159116
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- データソース種別
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- JaLC
- NDL
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