早期胃癌の増殖性に関する研究

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タイトル別名
  • STUDIES ON CELL PROLIFERATION IN EARLY GASTRIC CANCER
  • ソウキ イガン ノ ゾウショクセイ ニ カンスル ケンキュウ thymidine-H3 autoradiograph ニ ヨル シュジュ ノ イ シッカン ト ノ ヒカク ケントウ
  • COMPARISON OF LABELING INDEX IN EARLY GASTRIC CANCER AND OTHER DISEASES OF THE STOMACH, AS JUDGED BY THYMIDINE H-3 AUTORADIOGRAPH
  • thymidine-H<SUP>3</SUP>・autoradiograph による種々の胃疾患との比較検討

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抄録

In an attempt to study the mode of cell proliferation of the gastric epithelium in early cancer or other diseases of the stomach, a piece of tissue obtained by biopsy or operation was incubated in vitro with thymidine -H3 and autoradiograph was obtained.<BR>1. A high labeling cell index was found when the tissue from early cancer was used, indicating a marked proliferation in such tissue.<BR>2. No appreciable difference has been found in either labeling index with thymidine -H3 or cell proliferation between superficially spreading and penetrating growth type in early cancer. In addition, no difference in the labeling cell index with thymidine -H3 was found when judged by macroscopic classification, histologic evidence or severity of atypism.<BR>3. In advanced cancer, the labeling cell index with thymidine -H3 was higher in peripheral area than in central area. This suggested a high cell proliferating activity in the peripheral area. Furthermore, labeling cell index was high in early cancer than in peripheral area of advanced cancer. Circulatory disturbance in advanced cancer may explain this difference.<BR>4. So-called atypical epithelium did show a rather lower labeling cell index than the early cancer, suggesting a low proliferating activity.<BR>5 In peripheral area of stomach ulcer, the labeling cell index varied greatly from case to case, possibly because of complex nature in curative processes and recurrence of the ulcer.<BR>6. The technique using in vitro labeling cell index did not make possible to differentiate cancer from other diseases of the stomach.<BR>7. The labeling cell index did not correlate well with the type of Shichijo' s reaction.

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