卵巣機能と副腎皮質機能との関係に関する研究

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タイトル別名
  • STUDIES ON RELATION BETWEEN OVARIAN AND ADRENOCORTICAL FUNCTION
  • ランソウ キノウ ト フクジン ヒシツ キノウ ト ノ カンケイ ニ カンスル ケンキュウ

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Adrenocortical function of patients with menstrual disorders were investigated chiefly by assaying urinary 17-OHCS.<BR>1. Six women with normal menstruation were assayed for urinary 17-OHCS, and two peaks were observed during a menstrual cycle. The level in the luteal phase was significantly higher than in the follicular phase.<BR>2. Urinary 17-OHCS was assayed with 159 patients of menstrual disorders (9 with primary amenorrhea, 111 secondary amenorrhea, 33 with anovulatory cycle, and 6 with uterine amenorrhea).The value was high in many with anovulation and secondary amenorrhea. Especially in those with secondary amenorrrhea of less than 6 month duration, adrenocorical hyperfunction is assumed to play an important role as a causative factor, <BR>3, Tests for hypophyseal reserve (Su 4885 test) and for adrenocortical reserve (ACTH test) were performed with 16 patients with menstrual disorders. The result revealed that in no cast amenorrhea seemed to result from reduction in adrenocortical reserve, and that many exhibited hypothalamohypophyseal dysfunction. This, however, can not be considered as the cause of menstrual disorders, since there were also cases which showed the normal reserve, <BR>4. Many patients with functional uterine bleeding gave high urinary 17-OHCS level. None of these patients showed adrenocortical hypofunction.<BR>5. Three cases of Cushing syndrome had secondary amenorrhea of grade 2. Their estrogen activity was low, but their urinary gonadotrophin level was normal or high.<BR>6. Analysis of data from 28 cases with environmental menstrual disorders disclosed that in many, urinary 17-OHCS or 17-KS level was high, and gonadotrophin level was normal or low. This indicates that on the level of the hypophysis, hypercorticotrophism and hypogonadotrophism, especially of LH occurs concurrently. This is supposed to be an endocrinological feature of environmental menstrual disorders. This was confirmed also in animal experiments.

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