In vitroにおけるEhrlich腹水癌細胞のZn<SUP>65</SUP>摂取に関する研究 (2)

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  • STUDIES ON Zn<SUP>65</SUP> UPTAKE BY EHRLICH ASCITES CANCER CELLS IN VITRO
  • In vitro ニ オケル Ehrlich フクスイガン サイボウ ノ Zn65 セッシュ ニ カンスル ケンキュウ 2

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Ehrlich ascites cancer cells gradually took up Zn65 from their enviroment of 0.9% NaCl and Tris buffer medium, on incubation, at the temperature of 37°C.<BR>Change of temperature on incubation, pH of medium, and addition of carrier, amino acids, chelating agents and metal ions, changed the uptake of Zn65.<BR>1. Lower temperature of 19°C and 11°C on incubation, diminished the uptake.<BR>2. Within pH 4.9 to 8.1 range of medium, no changes occurred.<BR>3. Carrier inhibited the uptake.<BR>4. Some amino acids were added to the medium of 0. 9% NaCl to the final concentration of 10-3M. L- glutaihione, L-aspartic acid, and DL-and D-penillamine markedly inhibited, L-cysteine and glycine inhibited moderately.<BR>5. Some chelating agents were added to the medium of 0. 9% NaCl to various concentration. Only Ca EDTA at final 10-3M and 10-5M markedly inhibited. Dihidrothioctic acid at final 10-3M and riboflavin at final 200μg, modera tely inhibited, and Na citrate and α-thiola-ctoylglycine inhibited sligtly.<BR>6. Zn2+, Cu2+, Ni2+, Co2+, Fe2+ and Mn2+ at final 10-4M concentration in medium of Tris buffer, inhibited the uptake to various degree.

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