Influence of Change in Lighting Schedule on Circadian Variation of Uric Acid Metabolism

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  • YOKOZAWA Takako
    Department of Biochemistry, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University
  • KANAI Kumiko
    Department of Biochemistry, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University
  • OURA Hikokichi
    Department of Biochemistry, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University

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Other Title
  • 尿酸代謝リズムに及ぼす明暗変更の影響について
  • ニョウサン タイシャ リズム ニ オヨボス メイアン ヘンコウ ノ エイキョウ

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Abstract

The influence of change in the lighting schedule on the circadian variation of uric acid metabolism was observed in the rat.<BR>Under regular light-dark alternation, the level of serum uric acid and allantion was highest at 2pm and lowest at 2am. The circadian rhythm was also observed in enzyme activity of the liver. That is, the activity of xanthine oxidase showed a circadian variation with the same pattern as that of uric acid and allantoin. Uricase activity exhibited a circadian fluctuation, with the highest activity at 10am and the lowest at 6pm. However, rats exposed to constant light or dark manifested an abolition of the circadian rhythm of uric acid metabolism.

Journal

  • Eiyo To Shokuryo

    Eiyo To Shokuryo 31 (5), 497-500, 1978

    JAPAN SOCIETY OF NUTRITION AND FOOD SCIENCE

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