高糖質食または高脂肪食摂取ラットの脂肪組織の脂肪酸放出能とPTU投与への反応

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書誌事項

タイトル別名
  • Fatty Acid Release Rate of Adipose Tissue from Rats on a High Carbohydrate or a High Fat Diet and its Response to PTU Administration
  • コウ トウシツ ショク マタハ コウ シボウショク セッシュ ラット ノ シボ

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説明

The effect of a high carbohydrate or a high fat feeding on the lipolytic activity of epididymal fat pads was investigated with relation to the thyroidal function in rats. Male rats were ad libitum fed on either a high carbohydrate (carbohydrate 80 and fat 5% of total calorie) (HC) or a high fat (carbohydrate 45 and fat 40%) (HF) diet for 10 weeks, and each half of both groups were administered with 0.1% propylthiouracil (PTU) in drinking water for the final 12 days of the feeding period. Thyroid weight and oxygen consumption by gastrocnemius muscle homogenates of rats fed HF diet were greater thaa those of rats fed HC diet. The muscle oxygen consumption was markedly depressed by PTU administration in HF-fed rats but unaffected in HC-fed rats.<BR><I>In vitro</I>, norepinephrine stimulated lipolysis of epididymal fat pads was greater in HF-fed rats than in HC-fed rats. A depressive effect of PTU administration on the lipolysis without norepinephrine was observed only in HF-fed rats and the effect on lipolysis with norepinephrine was greater in HF-fed rats. The concentration of free fatty acid in serum was equal in HF-and HC-fed rats but significantly low in HF-fed rats treated with PTU.<BR>These findings suggest that a high fat feeding results in a high lipolytic activity of adipose tissue due to a high thyroidal function in rats.

収録刊行物

  • 栄養と食糧

    栄養と食糧 34 (4), 335-340, 1981

    公益社団法人 日本栄養・食糧学会

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