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IMMUNOMODULATIVE EFFECTS OF CHINESE HERBS IN MICE TREATED WITH CARCINOGEN
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- JIN RUT
- Department of Microbiology, Gunma University School of Medicine
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- MITSUISHI TOSHIMI
- Department of Microbiology, Gunma University School of Medicine
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- AKUZAWA YUKI
- Department of Medical Technology, Gunma University College of Medical Care and Technology
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- SATO SHINOBU
- Department of Legal Medicine, Gunma University School of Medicine
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- KODAMA KAZUE
- Third Department of Internal Medicine, Gunma University School of Medicine Maebashi
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- KURASHIGE SATONORI
- Department of Medical Technology, Gunma University College of Medical Care and Technology
Bibliographic Information
- Other Title
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- 和漢薬紫華栄の発ガン剤BBN 投与マウスの免疫応答に及ぼす影響
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Description
Extracts of Chinese herbs and their mixture “Shi-Ka-Ron” were administered with carcinogen, N-butyl-nitrosoamine (BBN), and their effects on macrophages and lymphocytes were studied. Peritoneal macrophages were significantly retarded both in their number and chemotactic activity by BBN treated. Blastogenic responsiveness to Concanavalin A of spleen lymphocytes also decreased significantly in BBN-treated mice. NK cell activity of lymphocytes was slightly suppressed by BBN treatment.<BR>Extract of Astragali radix showed protective effects on all 5 items studied. The number of macrophages and lymphocytes, and the functions of macrophages and lymphocytes maintained as same or more as normal levels in BBN plus Astragali extract-treated mice.<BR>Extract of Cnidii rhizoma showed the protective effects on the functions of macrophages and lymphocytes from BBN treatment but not on their numbers. E xtract of Lithospermi radix protected the retardation of lymphocyte function.<BR>“Shi-Ka-Ron” protected only chemotactic activity of macrophages and NK cell activity of lymphocytes but did not their numbers or blastogenic activity in spite of the mixture of herb extracts. These results suggest that the Chinese herbs may moderate each other's activity as mentioned from old time in China.
Journal
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- The KITAKANTO Medical Journal
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The KITAKANTO Medical Journal 44 (2), 125-133, 1994
The Kitakanto Medical Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282680308140288
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- NII Article ID
- 130003690586
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- ISSN
- 18836135
- 00231908
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed
