Denaturing Action of Typical Anionic Surfactants on Several Proteins

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  • 代表的アニオン界面活性剤の各種タンパク質に対する変性作用
  • ダイヒョウテキ アニオン カイメン カッセイザイ ノ カクシュ タンパクシツ

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The denaturing action of typical anionic surfactants, alkyl sulfate (AS), alkyl benzene sulfonate (LAS), α-olefin sulfonate (AOS) and sodium alkane sulfonate (SAS), on four different proteins, keratin, albumin, enzyme and lysosome membrane has been investigated by measuring liberation of sulfhydryl group and by enzyme inhibition. The results indicate that in general these surfactants have high denaturing potency for such proteins in the decreasing order of LAS≥AS>AOS≥SAS, although the potency varies considerably with the alkyl-chain length of the surfactants. Moreover, a relationship between the denaturing potency and the skin irritating action of these surfactants has been discussed.

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