甲状腺機能亢進症における血清ガストリン分泌動態に関する研究

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タイトル別名
  • STUDIES ON THE GASTRIN SECRETION IN HYPERTHYROIDISM
  • コウジョウセン キノウ コウシンショウ ニ オケル ケッセイ ガストリン ブン

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Increases in serum concentrations of immunoreactive gastrin in patients with hyperthyroidism have been reported by several investigators. However, no detailed information is available about the mechanism responsible for the high gastrin levels. The present study was undertaken to elucidate the mechanism of abnormal secretion of gastrin in hyperthyroidism.<BR>The results obtained herein were as follows : <BR>1. The mean fasting serum gastrin concentration for the patients with untreated hyperthyroidism was significantly higher than in normal subjects.<BR>2. No significant correlation was observed between the basal serum gastrin levels and any of the thyroid function tests determined.<BR>3. The high gastrin levels in hyperthyroid patients appeared to be lowered after treatment with antithyroid drug. However, serum gastrin levels in some treated patients were still higher than that of normal subjects, even when they became euthyroid after therapy.<BR>4. No rise in serum gastrin levels occurred when normal subjects were treated with daily dose of 75 pig triiodothyronine for 8 days.<BR>5. Decreased gastric acidity, as determined by BAO, MAO, BSVR and MSVR, was observed in patients with hyperthyroidism as compared with normal subjects : Such decreased gastric acidity tended to be elevated by antithyroid drug therapy.<BR>6. Histologic examination of gastric mucosa in hyperthyroid patients showed superficial or atrophic gastritis, associated with lower gastric acidity.<BR>7. No difference in serum calcium concentrations was observed between hyperthyroid patients and normal subjects.<BR>8. Serum gastrin rose significantly from the basal levels in hyperthyroidism during arginine drip infusion. However, no difference in the per cent of the increase in gastrin levels was observed between hyperthyroid patients and normal subjects.<BR>The present findings provide evidence that chronic stimulation of excess thyroid hormone is an important determinant in inducing hypergastrinemia, associated with decreased gastric acid secretion.

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