アスピリンの血小板凝集抑制作用に関する研究

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タイトル別名
  • THE EFFECT OF ASPIRIN ON PLATELET FUNCTION AND ITS MECHANISM
  • アスピリン ノ ケッショウバン ギョウシュウ ヨクセイ サヨウ ニカンスルケン

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The inhibitory effect of aspirin (ASA) on platelet function has been well known, but the inhibitory mechanism has not been known yet. In this study, the effects of ASA on the aggregation and release reaction of rabbit platelets and the inhibitory site of ASA were investigated, and the following results were obtained : <BR>1) In a series of in vitro experiment, the addition of 10-6 M of ASA to normal citrated platelet-rich plasma prolonged_ lag time and suppressed the maximum rate of the platelet aggregation induced by collagen. The addition of more than 10-4 M of ASA completely inhibited collagen-induced platelet aggregation. No significant inhibition of primary aggregation induced by ADP was observed.<BR>2) ASA inhibited collagen-or ADP-induced release of both platelet factor 3 and serotonin from platelets.<BR>3) Significant inhibition of the collagen-induced platelet aggregation become evident as early as 1 to 2 hrs and was maintained till 48 hrs, following the single dose of more than 0.05g of ASA. Increase in oral dose of ASA ingested to 1.0g did not enhance the inhibitory effect. Ingestion of 0.01g of ASA resulted in lesser and transient inhibition in the collagen-induced platelet aggregation.<BR>4) Coagulation parameters were not influenced by ingestion of ASA except for a slight decrease in plasma concentration of fibrinogen.<BR>5) In vitro study with washed or gel-filtered platelet revealed that the inhibitory effect of ASA on collagen-induced aggregation of platelets is mainly due to the direct modification of the platelet itself rather than to change of a plasma cofactor.

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