抗唾液免疫ニワトリ血清中の抗ルイス抗体について

書誌事項

タイトル別名
  • ANTI-LEWIS CHICKEN SERA IMMUNIZED WITH HUNAN SALIVA
  • コウ ダエキ メンエキ ニワトリ ケッセイチュウ ノ コウ ルイス コウタイ

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抄録

Anti-Lea and anti-Leb agglutinins and precipitins were produced in chicken sera immunized with human Le (a + b-) non-secretor and Le (a-b +) secretor saliva respectively. The chicken anti-Lewis agglutinins reacted with enzyme treated red cells. The results of the agglutination and precipitation inhibition tests with mono-and oligosaccharides indicated that the chicken anti-Lea antibodies had stronger affinity for nonreducing end β-galactosyl residue joined by a (1→3) linkage to N-acetylglucosamine than a (1→4) linked α-fucosyl residue. The chicken anti-Leb antibodies were specifically inhibited by lacto-N-difucohexaose I. Therefore chicken anti-Leb had potent affinity for adjacent nonreducing end α-fucosylresiduesioined by (1→2) and (1→4) linkage.

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