Inhibition of Tyrosinase Activity by 6- [(8 <I>Z</I>, 11 <I>Z</I>) -8, 11, 14-Pentadecatrienyl] salicylic Acid Derivatives

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  • NOMURA Masato
    Department of Industrial Chemistry, Faculty of Engineering, Kinki University
  • FUJIHARA Yoshihito
    Department of Industrial Chemistry, Faculty of Engineering, Kinki University

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  • 6- [(8<I>Z</I>, 11<I>Z</I>) -8, 11, 14-ペンタデカトリエニル] サリチル酸誘導体のチロシナーゼ活性阻害について
  • 6 8Z 11Z 8 11 14 ペンタデカトリエニル サリチルサン ユウドウ

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For the effective utilization of compounds obtained from nature, we synthesized derivatives considered to possibly have physiological activity, using 6- [(8 Z, 11 Z) -8, 11, 14-pentadecatrienyl] salicylic acid (1) from cashew nut shell oil as the starting material. Eight derivatives were obtained via acetylation, methylation and/or oxidation of (1). They were examined for capacity to inhibit tyrosinase and found to inhibit its activity more than (1).

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