Tissue Incorporation and Excretion of Dietary Nickel-catalyst in Rats

DOI Web Site Web Site 1 Citations 14 References

Bibliographic Information

Other Title
  • 食じ性ニッケル触媒のラット組織への取り込み及び排せつ
  • ショクジセイ ニッケル ショクバイ ノ ラット ソシキ エ ノ トリコミ オヨ

Search this article

Abstract

Examination was made of the biochemical and histological effects of a nickel (Ni) catalyst obtained following the hydrogenation of oils and fats. Five groups of male rats (5 per group) were fed diets containing different amounts of the Ni catalyst (0 : control, 20, 50, 200 and 500 ppm as Ni) for 4 weeks. A comparison was made of growth and tissue weights, Ni content in various tissues, and fecal and urinary excretion of Ni from the rats. Liver and kidney morphology was also observed.<BR>1) Body weight gain and food intake in all Ni-supplemented groups were the same as in the control group. Also, weights of liver, heart, lung, kidney, spleen, brain and testis in all Ni-supplemented groups were not different from those of the control group.<BR>2) Liver, heart, lung, spleen, brain, testis, fur and blood nickle content was less than 0.6 ppm in all Ni-supplemented groups. Kidney in the 500 ppm Ni-supplemented group showed a relatively high level of Ni, about 1.6 ppm compared to less than 0.2 ppm in the 0 to 50 ppm groups. The value for the 200 ppm group was intermediate. Dietary Ni catalyst was excreted almost completely into the feces, with only small amounts found in the urine. Fecal excretion from all Ni-supplemented groups constituted more than 98% the total excretion.<BR>3) Microscopic observation of liver and kidney disclosed no histological anomalities even in the 500 ppm Ni-supplemented group.

Journal

Citations (1)*help

See more

References(14)*help

See more

Details 詳細情報について

Report a problem

Back to top