Molecular Recognition of Cyclophanes as Artificial Receptors

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  • MURAKAMI Yukito
    Department of Chemical Science and Technology, Faculty of Engineering, Kyushu University
  • HAYASHIDA Osamu
    Department of Chemical Science and Technology, Faculty of Engineering, Kyushu University

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  • 人工レセプターとしてのシクロファン類の分子認識
  • ジンコウ レセプター トシテノ シクロファンルイ ノ ブンシ ニンシキ

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Abstract

Novel cage-type cyclophanes bearing L-and D-valine residues and capable of providing a three-dimensionally extended cavity were prepared in order to simulate specific functions of naturally occurring receptors. The cage-type hosts provide relatively apolar microenvironments, which are well shielded from the bulk aqueous phase, for hydrophobic guests. Moreover, the cage-type hosts bearing L-and D-valine residues in their respective bridging segments afford S-and R-helical cavities, respectively.The helically twisted cavities of the hosts furnish conformation-enforced microenvironments for chiral recognition of enantiomeric guests, such as bilirubin-IXα, as well as diastereomeric guests, such as steroid hormones.

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