Negative pressure wound therapy for limb salvage

DOI Web Site 25 References
  • Matsuzaki Kyoichi
    Department of Plastic and Reconstructive Surgery, Kawasaki Municipal Tama Hospital, Department of Plastic and Reconstructive Surgery, St. Marianna University School of Medicine

Bibliographic Information

Other Title
  • 下肢救済に応用される局所陰圧閉鎖療法
  • 難治性創傷の最新治療(2)下肢救済に応用される局所陰圧閉鎖療法
  • ナンチセイ ソウショウ ノ サイシン チリョウ(2)カシ キュウサイ ニ オウヨウ サレル キョクショ インアツ ヘイサ リョウホウ

Search this article

Abstract

In 2010, Negative pressure wound therapy began to be covered under the Japanese National Health Insurance, resulting in significant progress for limb salvage. Negative pressure exerts mechanical stress on the wound for its therapeutic effect and differs from conventional wound therapy. Macrodeformation and microdeformation occur due to mechanical stimulation. Macrodeformation draws together the edges of the wound and removes exudate and infectious materials. Removal of exudate changes the interstitial-fluid pressure gradient, reduces edema, and increases blood flow. Microdeformation causes the cell shape to change, resulting in signal transmission to the nucleus and gene transcription. Consequently, cell proliferation and differentiation occur. Furthermore, metabolism increases, growth factor and cytokine expression changes, granulation tissue formation is promoted, blood flow increases, and wound healing is promoted. It is important to use this procedure with a thorough understanding of its indications and contraindications in order to optimize its features.

Journal

References(25)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top