Extracellular Matrix in Keloids

DOI Open Access
  • Aramaki-Hattori Noriko
    Department of Plastic and Reconstructive Surgery, Keio University, School of Medicine
  • Isogai Zenzo
    Division of Dermatology and Connective Tissue Medicine, Department of Advanced Medicine, National Center for Geriatrics and Gerontology
  • Okabe Keisuke
    Department of Plastic and Reconstructive Surgery, Keio University, School of Medicine
  • Kishi Kazuo
    Department of Plastic and Reconstructive Surgery, Keio University, School of Medicine

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Other Title
  • 細胞外マトリックスから見たケロイド

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Description

Keloids are an abnormal response to wound healing, leading to enlarged and unusual distributions of extracellular matrix (ECM). They involve red, raised formation of fibrous scar tissue caused by excessive tissue repair in response to trauma or incision. Histologically, thick and hyalinized collagen bundles are often found in keloids. Although it has been reported that collagen and glycosaminoglycan show abnormal excess deposition and elastic fiber is reduced in keloid lesions, the role of abnormal ECM in keloids is still unclear.<br>This paper presents a review of previous papers about the extracellular matrix in keloids and also mentions our study of vesican in keloids.

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