書誌事項
- タイトル別名
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- Total Synthesis and Stereochemistry Revision of Mannopeptimycin Aglycone
- マンノペプチマイシンアグリコン ノ ゴウセイ ト リッタイ ハイチ テイセイ
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<p>Mannopeptimycin is an attractive drug candidate due to its strong antimicrobial activity against drug-resistant strains. However, detailed elucidation of structure-activity relationship and its mode of action has been hampered because the chemical synthesis of the densely functionalized aglycone moiety consisting of cyclic hexapeptide was not established. The key point in the synthesis of the aglycone was the construction of densely functionalized unnatural amino acids, Aiha-A and Aiha-B. This account describes isolation, structural determination of mannopeptimycins, previously reported synthesis of Aiha-A and Aiha-B as well as our short-step, high-yielding synthesis of Aihas leading to the first synthesis of mannopeptimycin aglycone with stereochemistry revision of originally proposed structure.</p>
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 75 (12), 1274-1285, 2017
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390282680315924608
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- NII論文ID
- 130006248379
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- NII書誌ID
- AN0024521X
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- ISSN
- 18836526
- 00379980
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- NDL書誌ID
- 028729266
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可