Natural Product Chemistry based on Isolation and Structure Elucidation

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  • Asai Teigo
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo

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  • 単離・構造決定に立脚する天然物化学研究の展開
  • タンリ ・ コウゾウ ケッテイ ニ リッキャク スル テンネンブツ カガク ケンキュウ ノ テンカイ

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<p>Isolation and structure elucidation is a basic skill for natural product chemistry. The skill is a powerful tool to unveil cryptic diversity of natural products and see a beautiful world of organic molecules in nature. Based on isolation and structure elucidation skill, we have carried researches on natural product chemistry, chemical investigation of plant glandular trichome exudates, natural product discovery by epigenetically activating fungal silent biosynthetic gene clusters, semi-synthetically production of structurally diverse pseudo-natural polyketides. And, now we are working on “post-genomic natural product discovery based on Aspergillus oryzae heterologous expression system”. In this review, I show the research overviews of above topics including my experience and what I feel at that time.</p>

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