書誌事項
- タイトル別名
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- Development and Functionalization of Structural Mimics of Multipass Transmembrane Proteins
- フクスウカイマク カンツウガタ タンパクシツ ノ コウゾウ モホウ ト キノウ カイハツ
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Multiblock amphiphiles adopting a multipass transmembrane (MTM) structure on a bilayer membrane have been developed by mimicking the molecular structures of MTM proteins. The amphiphiles are composed of alternative hydrophobic and hydrophilic parts. The hydrophobic parts that penetrate the membrane consist of a fluorescent aromatic group, so that absorption and fluorescent spectroscopy allows the characterization of the assembling/disassembling states of the hydrophobic parts. The spectroscopic analyses revealed that the tetra block amphiphile, bearing four hydrophobic parts, forms intramolecular stacking of the aromatic portions within the membrane, indicating the formation of an MTM structure. Moreover, the tetra block amphiphile shows ion transportation through the membrane following Eisenman sequence XI, where the four molecules self-assemble into a dynamic ion channel with a milli second scale opening-closing motion. The hierarchical construction of a higher-order structure by self-assembly of foldamers can be a rational design of programmable functional molecular organisms.
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 71 (10), 1045-1050, 2013
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390282680316906240
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- NII論文ID
- 10031203356
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- NII書誌ID
- AN0024521X
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- COI
- 1:CAS:528:DC%2BC3sXhs1Oiu7vK
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- ISSN
- 18836526
- 00379980
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- NDL書誌ID
- 024935707
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- KAKEN
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- 抄録ライセンスフラグ
- 使用不可