Nickel-Catalyzed Direct Coupling of Heteroarenes

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  • ニッケル触媒を用いたヘテロ芳香族化合物の直接的カップリング
  • ニッケル ショクバイ オ モチイタ ヘテロ ホウコウゾク カゴウブツ ノ チョクセツテキ カップリング

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Abstract

Nickel-catalyzed cross-coupling reactions have recently been receiving significant attention from the synthetic community as a way to construct carbon-carbon or carbon-heteroatom bonds, because nickel catalysts are less expensive and less toxic than palladium catalysts.<br>We herein describe our recent developments in nickel-catalyzed biaryl coupling methodology, along with mechanistic studies and applications to the synthesis of natural products and pharmaceuticals. In particular, we focus on nickel-catalyzed direct coupling reactions in which “unreactive” bonds such as C-H, C-O, and C-C bonds are converted into biaryl moieties.

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