書誌事項
- タイトル別名
-
- Effective Synthesis of Oligosaccharide under Microfluidic Conditions
- フローマイクロ ゴウセイ オ リヨウ シタ コウリツテキ ナ トウサ ゴウセイ
この論文をさがす
説明
Continuous microflow synthesis is an innovative technology for chemical processes from small-scale synthesis to large-scale production. This technology enables fast and efficient mixing, rapid heating and cooling, strict temperature control, precise residence time control, and effective mass transfer. Moreover, once the reaction conditions are optimized for a small-scale operation, the same conditions are directly applicable to large-scale synthesis under the flow process. We successfully developed the alcohol dehydration process using microreactor and applied it to the large-scale production of saturated terpenoid pristane, which has been used as an adjuvant for monoclonal antibody production in mice. We then have been investigating to apply the advantageous features of the microfluidic systems to oligosaccharide synthesis. Our successful examples include α-sialylation, β-mannosylation, N-glycosylation on asparagine, α-selective glycosylation of 3-deoxy-d-manno-2-octulosonic acid (Kdo), and photo-bromination of toluene derivatives.
収録刊行物
-
- 有機合成化学協会誌
-
有機合成化学協会誌 73 (5), 452-459, 2015
公益社団法人 有機合成化学協会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282680318406272
-
- NII論文ID
- 130005077685
-
- NII書誌ID
- AN0024521X
-
- ISSN
- 18836526
- 00379980
-
- NDL書誌ID
- 026396355
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDLサーチ
- Crossref
- CiNii Articles
- KAKEN
- OpenAIRE
-
- 抄録ライセンスフラグ
- 使用不可
