Estimation of Controlled Drug-release Behavior of Nano-porous Silica Micro Particles and Their Biocompatibility

DOI Open Access
  • SEITOKU Eri
    Graduate School of Dental Medicine, Department of Restorative Densistry, Fucalty of Dental Medicine,
  • ERA Yuko
    Graduate School of Dental Medicine, Department of Biomaterials and Bioengineering, Fucalty of Dental Medicine,
  • NAKANISHI Ko
    Department of Orthodontics, Fucalty of Dental Medicine,
  • BANDO Yosuke
    Graduate School of Dental Medicine, Department of Orthodontics, Fucalty of Dental Medicine,
  • KAKUDA Shinichi
    Department of Restorative Densistry, Fucalty of Dental Medicine,
  • NAKAMURA Koichi
    Department of Dentistry for Children and Disabled Person, Fucalty of Dental Medicine, Hokkaido University, Sapporo, Japan
  • KUSAKA Teruo
    Department of Biomaterials and Bioengineering, Fucalty of Dental Medicine,
  • ABE Shigeaki
    Department of Biomaterials and Bioengineering, Fucalty of Dental Medicine,
  • NAKAMURA Mariko
    School of Health Science, Kyushu University of Health and Welfare, Nobeoka, Japan Japan
  • YAWAKA Yasutaka
    Department of Dentistry for Children and Disabled Person, Fucalty of Dental Medicine, Hokkaido University, Sapporo, Japan
  • IIDA Junichiro
    Department of Orthodontics, Fucalty of Dental Medicine,
  • YOSHIDA Yasuhiro
    Department of Biomaterials and Bioengineering, Fucalty of Dental Medicine,
  • SANO Hidehiko
    Department of Restorative Densistry, Fucalty of Dental Medicine,

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Abstract

<p>In this study, we investigated the controlled release behavior of a model drug from nanoporous silica microparticles (NPSM) contained in dental glass ionomer cement (GIC). NPSM released model drug molecules gradually in water for 2 weeks when they were contained in GIC. In contrast, GIC-only specimens released the molecule rapidly. To estimate the cytocompatibility of NPSM, osteoblastic cells were exposed to particles with various concentrations. At a concentration of 30 ppm, cell viability remained identical to that without exposure. In addition, mixing the particles did not affect their mechanical properties. These results suggest that NPSM can be used as a sustainable drug-release dental material.</p>

Journal

  • Nano Biomedicine

    Nano Biomedicine 9 (2), 112-116, 2017

    Nano Biomedical Society

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