Alveolar Epithelium Cellular Uptake of Nanoparticles Depending on Surface Modification and Potential

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  • ナノ粒子表面修飾，表面電位による肺胞上皮細胞への取り込み

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Recent studies have shown that various physicochemical characters of nanoparticles have to be comprehensively concerned about their risk assessment. However, any researches haven't yet carried out to determine about depending of particles modification or surface potential.<br> In this study, we examined that amounts of alveolar epithelium (A549) cellular uptake rely on particles modification or surface potential by confocal scanning laser microscopy imaging and flow cytometry. Then, the longer exposure time, the more cells taken up nanoparticles, in particular carboxylated particles were noticeable, though it was not able to show about the relativity between surface potential and cellular uptake.

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