ジフェニル・ヒダントイン (ダイランチン) 投薬によるネコの歯肉の初期変化に関する研究

DOI
  • 中嶋 善仁
    Clinic of Periodontia, Department of Operative Dentistry, Tokyo Medical and Dental University

書誌事項

タイトル別名
  • The Experimental Study of Gingival Response to Administration of Sodium Diphenyl Hydantoin (Dilantin) in Cats
公開日
1963
DOI
  • 10.14833/perio1959.5.2_66
公開者
特定非営利活動法人 日本歯周病学会

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説明

The purpose of this experiment was to clarify the role of the gingivitis on Dilantin gingival hyperplasia.<br>As the experimental animals, 18 adult cats were used. They were divided in two groups, 14 cats' group and 4 cats' one. The former was used as the experimental group which had been administered Dilantin for 1 day, 2 days, 4 days, 7 days, 14 days. and 28 days respectively, and the latter was used as the control.<br>To compare the difference of response to Dilantin between inflammatry gingivae and normal gingivae in the same oral cavity, the following procedures were employed.<br>In all cats, the left side teeth were ligated with thread #80 so as to make chronic inflammatry changes of gingivae with its continuous irritation, and on the other hand, the right side were kept free.<br>These experimental animals were examined macroscopically and histologically.<br>The results were as follows:-<br>1) In 5 of 14 cats of experimental group, gingival response to Dilantin was observed.<br>2) The response was limited on gingival margin.<br>3) In almost every animals, severe response was much observed in inflammatry part as compared with normal part.<br>4) Gingival inflammation may be one of the causative factors of Dilantin gingival hyperplasia.<br>5) Dilantin gingival hyperplasia was seemed to be accelerated by gingival inflammation.

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