Ultrastructural Patterns of Interactions between Murine Lung Macrophages and Yeast Cells of <I>Cryptococcus neoformans</I> Strains with Different Virulence

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  • Stepanova Amaliya
    North-Western State Medical University named after I.I. Mechnikov: Kashkin Research Institute of Medical Mycology of St. Petersburg
  • Vasilyeva Natalia
    North-Western State Medical University named after I.I. Mechnikov: Kashkin Research Institute of Medical Mycology of St. Petersburg
  • Yamaguchi Masashi
    Medical Mycology Research Center, Chiba University
  • Chibana Hiroji
    Medical Mycology Research Center, Chiba University
  • Bosak Iliya
    North-Western State Medical University named after I.I. Mechnikov: Kashkin Research Institute of Medical Mycology of St. Petersburg
  • Filippova Larisa
    North-Western State Medical University named after I.I. Mechnikov: Kashkin Research Institute of Medical Mycology of St. Petersburg

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  • Ultrastructural Patterns of Interactions between Murine Lung Macrophages and Yeast Cells of Cryptococcus neoformans Strains with Different Virulence

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This article presents the ultrastructural patterns of interactions between the murine lung macrophages and cells of low- (RKPGY-881, -1165, -1178) and high-virulence (RKPGY-1090, -1095, -1106) strains of Cryptococcus neoformans at the seventh post-experimental day. It was found that if macrophages ingest living yeast cells, the latter can: 1) become completely free from polysaccharide capsules, after that their contents undergo lysis, and cell wall debris are extruded from the macrophage (first scenario); 2) become partly free from their capsules, destroy the phagosomal plasma membrane and induce destructive processes inside the macrophage causing their death (second scenario); or 3) not lose their capsules and localize inside macrophage in latent state (third scenario). Macrophages can also ingest senescent and dead C. neoformans cells surrounded by capsules that are lost at the ingesting and phagosome stages (fourth scenario). The study revealed the dependence of cell-mediated immunity on the stage of development of ingested C. neoformans yeast cells. Here we describe a new mechanism of capsular polysaccharide elimination of C. neoformans yeast cells by murine macrophages.

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