Anti-<I>Candida</I> Activity of Aroma Candy and Its Protective Activity Against Murine Oral Candidiasis
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- Hayama Kazumi
- Teikyo University Institute of Medical Mycology
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- Takahashi Miki
- Teikyo University Institute of Medical Mycology
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- Suzuki Motofumi
- Teikyo University Institute of Medical Mycology
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- Ezawa Kunio
- Teikyo University Institute of Medical Mycology
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- Yamazaki Masatoshi
- Teikyo University Institute of Medical Mycology
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- Matsukawa Taiji
- Technology Development Section, UHA Mikakuto Co., Ltd. Department of Bioscience, Graduate School of Science and Technology, Shizuoka University
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- Kishi Akinobu
- Technology Development Section, UHA Mikakuto Co., Ltd.
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- Sato Nobuya
- Technology Development Section, UHA Mikakuto Co., Ltd.
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- Abe Shigeru
- Teikyo University Institute of Medical Mycology
Bibliographic Information
- Other Title
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- アロマキャンディのカンジダ発育阻止能とマウス口腔カンジダ症に対する防御効果
- アロマキャンディ ノ カンジダ ハツイク ソシノウ ト マウス コウコウ カンジダショウ ニ タイスル ボウギョ コウカ
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Abstract
A daily eatable candy that has possible protective activity against oral candidiasis was experimentally produced. The candy was made from reduced-maltose as main constituent and from several natural products, such as oligonol (depolymerized polyphenols derived from lychee), cinnamon (cassia), citral, and capric acid, which are known to have anti-Candida activity in vitro and in vivo. The candy effectively inhibited the mycelial growth of C. albicans, even when it was diluted 1,000 times with culture media. We assessed the protective activity of the candy against murine candidiasis. When 50μl of candy dissolved and diluted 4 times with water was administered 3 times into the oral cavity of Candida infected mice, the score of lesions on the Candida-infected tongues improved on day 2. These findings suggest that this candy has potential as food that provides protective activity against oral candidiasis.
Journal
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- Medical Mycology Journal
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Medical Mycology Journal 56 (1), J23-J29, 2015
The Japanese Society for Medical Mycology
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Keywords
Details 詳細情報について
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- CRID
- 1390282680374174080
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- NII Article ID
- 130005064304
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- NII Book ID
- AA12518136
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- ISSN
- 2186165X
- 18820476
- 21856486
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- NDL BIB ID
- 026079615
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- PubMed
- 25855024
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed