Antifungal susceptibility and drug-resistant mechanism of <I>Trichosporon</I>
-
- Kushima Hisako
- Department of Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine Department of Respiratory Medicine, Fukuoka University Hospital
-
- Tokimatsu Issei
- Department of Infection Control and Prevention, Kobe University Hospital
-
- Ishii Hiroshi
- Department of Respiratory Medicine, Fukuoka University Hospital
-
- Kadota Jun-ichi
- Department of Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine
Bibliographic Information
- Other Title
-
- トリコスポロンの抗真菌薬感受性と耐性機構
- トリコスポロン ノ コウシンキンヤク カンジュセイ ト タイセイ キコウ
Search this article
Abstract
Most cases of deep-seated trichosporonosis develop in patients with neutropenia, but it has recently been reported that breakthrough infections with Trichosporon species can develop during the use of candin family of antifungal agents. This is due to the primary resistance of the causal fungus, Trichosporon asahii (T. asahii), to the candin agents. On the other hand, there has been a case report of infection with Trichosporon that presented high-level resistance to the azole family of antifungal agents. Therefore, the possibility that the frequent use of azole agents may lead to secondary resistance to these agents is a cause for concern. Since trichosporonosis is a relatively rare infectious disease, there has been no established breakpoint for this fungus to various antifungal agents, wherein we cannot precisely confirm its sensitivity or resistance to the agents. However, our experiment demonstrated one of the processes for acquired drug resistance, wherein the minimal inhibitory concentration of fluconazole for T. asahii was markedly elevated after its long-term in vitro exposure to the drug. Although the mechanisms for drug-resistance of Trichosporon species are unknown, it is supposed that they are the same as the mechanisms found in Candida and Aspergillus species, namely, modification of target molecules or decrease of access to the molecules. Since cases of trichosporonosis are likely to increase in the future, we believe that there is an urgent need to establish the breakpoint for T. asahii based on large-scale drug sensitivity tests, as well as to elucidate its drug-resistance mechanisms.
Journal
-
- Medical Mycology Journal
-
Medical Mycology Journal 56 (4), J123-J128, 2015
The Japanese Society for Medical Mycology
- Tweet
Details 詳細情報について
-
- CRID
- 1390282680374994048
-
- NII Article ID
- 130005111262
-
- NII Book ID
- AA12518136
-
- ISSN
- 2186165X
- 18820476
- 21856486
-
- NDL BIB ID
- 026840211
-
- PubMed
- 26617108
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed