一酸化窒素長期動物暴露実験

DOI 被引用文献1件
  • 織田 肇
    Osaka Prefectural Institute of Public Health, Division of Environmental Health Research
  • 野上 浩志
    Osaka Prefectural Institute of Public Health, Division of Environmental Health Research
  • 楠本 繁子
    Osaka Prefectural Institute of Public Health, Division of Environmental Health Research
  • 中島 泰知
    Osaka Prefectural Institute of Public Health, Division of Environmental Health Research
  • 倉田 明彦
    Hyogo College of Medicine, 2nd Department of Pathology
  • 今井 清博
    Medical School, Osaka University, Department of Physico-Chemical Physiology

書誌事項

タイトル別名
  • Long-term Exposure to Nitric Oxide in Mice

この論文をさがす

説明

For a long-term exposure study of nitric oxide, JCL-ICR female mice were exposed to 10 ppm nitric oxide (contamined with 1-1.5 ppm nitrogen dioxide) for half a year. A part of 240 exposed mice and 240 control mice were sacrificed 2 weeks, 2, 4 and 6.5 months after the start of exposure and examined. Increases in lung weight and leucocyte counts, and a decrease in cholinesterase activity of blood were noted in the exposed group. Formation of Heinz-body in the red blood cell, and increases in spleen weight and total bilirubin suggested that destruction of red blood cell was facilitated by NO exposure. Nitrosylhemoglobin contents were constant even after the NO exposure were prolonged for half a year. Methemoglobin was not detected photometrically in the blood of mice, but a component having a peak at 620 nm which suggested the formation of sulfhemoglobin and a component with g-value of 6 by electron spin resonance measurement were found in the exposed group. Slight decrease in oxygen affinity of blood in the exposed group were observed by the measurement of oxygen dissociation curve of red blood cell suspension, but the anoxic histological findings of tissues were not present in the organs such as brains and hearts. Degenerative and necrotic changes, and subsequent hyperplasia of bronchiolar epitheliums, and dilatation of alveolar walls were noted in the exposed group in histological examinations. These changes, however, might not be attributable to the effect of nitric oxide alone in the present study because of the presence of contamination with nitrogen dioxide in the exposure gas, so further detail should be studied.

収録刊行物

  • 大気汚染研究

    大気汚染研究 11 (3), 150-160, 1976

    公益社団法人 大気環境学会

被引用文献 (1)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ