Effects of Enteric-coated Lactoferrin Tablets Containing <i>Lactobacillus brevis</i> subsp. <i>coagulans</i> on Fecal Properties, Defecation Frequency and Intestinal Microbiota of Japanese Women with a Tendency for Constipation: a Randomized Placebo-controlled Crossover Study
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- SUZUKI Noriyuki
- Research and Development Headquarters, Lion Corporation
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- MURAKOSHI Michiaki
- Kyoto Prefectural University of Medicine Research and Development Headquarters, Lion Corporation
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- ONO Tomoji
- Research and Development Headquarters, Lion Corporation
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- MORISHITA Satoru
- Research and Development Headquarters, Lion Corporation
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- KOIDE Misao
- Research and Development Headquarters, Lion Corporation
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- BAE Min Jung
- Department of Applied Biological Chemistry, University of Tokyo
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- TOTSUKA Mamoru
- Department of Applied Biological Chemistry, University of Tokyo
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- SHIMIZU Makoto
- Department of Applied Biological Chemistry, University of Tokyo
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- SUGIYAMA Keikichi
- Ritsumeikan Global Innovation Research Organization, Ritsumeikan University Research and Development Headquarters, Lion Corporation
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- NISHINO Hoyoku
- Kyoto Prefectural University of Medicine Ritsumeikan Global Innovation Research Organization, Ritsumeikan University
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- IIDA Norio
- Research and Development Headquarters, Lion Corporation
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Description
The effects of oral administration of enteric-coated tablets containing lactoferrin (LF; 100 mg/tablet) and heat-killed Lactobacillus brevis subsp. coagulans FREM BP-4693 (LB; 6×109 bacteria/tablet) on fecal properties were examined in 32 Japanese women (20–60 years of age) with a tendency for constipation (defecation frequency at equal to or less than 10 times/2 weeks) by a double-blind placebo-controlled crossover design. A significant increase in defecation days per week was obserbed in the subjects who ingested the tablets containing LF and LB compared with the placebo group. The number of bifidobacteria in feces also significantly increased compared with the placebo group. In an in vitro study, LF and tryptic hydrolysate of LF, but not peptic hydrolysate of LF, upregulated the growth of Bifidobacterium longum ATCC15707 when added to the culture. These results demonstrate the capability of the enteric-coated tablets containing LF and LB in improving intestinal function and suggest that they have a growth promoting function for bifidobacteria.
Journal
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- Bioscience of Microbiota, Food and Health
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Bioscience of Microbiota, Food and Health 32 (1), 13-21, 2013
BMFH Press
